Series 21, Episode 42 airs Tuesday 15th October at 20:00 on BBC One.

Frankie returns to Holby and is keen to take baby Isla back. A worried Essie doesn’t believe Frankie is truly ready to be a mother – how does Essie convince Frankie that Isla is better off with her before it’s too late?

Serena returns to the AAU and clashes with top neurosurgeon Max McGerry, who has a radical idea to treat Ric’s condition. Ric is forced to think about his options and makes his decision.

Jac returns from holiday and asserts her authority over an overworked and stressed out Kian.